The Global Pairwise Approach to Radiation Hybrid Mapping
نویسندگان
چکیده
A new method for constructing maps from radiation hybrid data is proposed. It uses maximization of a pseudo-likelihood based on information from all marker pairs. The pseudo-likelihood is a relatively smooth function of the marker position, allowing us to use gradient-based computational tools. Multi-dimensional scaling is used to provide starting positions for the markers. The method is fully automatic, making it possible to nd a good map for a hundred markers in a few minutes. Information from anchor markers can also be incorporated in a natural way.
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